Simultaneous determination of itraconazole, hydroxy-itraconazole and amphotericin B in human plasma by HPLC with photodiode array detection.
Identifieur interne : 001394 ( France/Analysis ); précédent : 001393; suivant : 001395Simultaneous determination of itraconazole, hydroxy-itraconazole and amphotericin B in human plasma by HPLC with photodiode array detection.
Auteurs : C. Lacroix [France] ; F. Wojciechowski ; P. DangerSource :
- Annales de biologie clinique [ 0003-3898 ] ; 1995.
English descriptors
- KwdEn :
- MESH :
- chemical , analogs & derivatives : Itraconazole.
- chemical , blood : Amphotericin B, Antifungal Agents, Itraconazole.
- chemical , therapeutic use : Amphotericin B, Antifungal Agents, Itraconazole.
- drug therapy : Mycoses.
- methods : Chromatography, High Pressure Liquid.
- Humans.
Abstract
A method for the fast analysis of itraconazole, hydroxy-itraconazole and amphotericin B is described which has the advantage of speed and specificity. The method is based on methanolic extraction of the compounds from plasma, followed by reverse-phase high-performance liquid chromatography with two detection wavelengths (263 and 405 nm). The extraction step provides > or = 94% recovery and the response of the detection system is linear from 50 to 5000 ng/ml. No other drugs have been found to interfere with the assay.
PubMed: 7574117
Affiliations:
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pubmed:7574117Le document en format XML
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Danger</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1995">1995</date><idno type="RBID">pubmed:7574117</idno><idno type="pmid">7574117</idno><idno type="wicri:Area/PubMed/Corpus">000423</idno><idno type="wicri:Area/PubMed/Curation">000423</idno><idno type="wicri:Area/PubMed/Checkpoint">000423</idno><idno type="wicri:Area/Ncbi/Merge">000597</idno><idno type="wicri:Area/Ncbi/Curation">000597</idno><idno type="wicri:Area/Ncbi/Checkpoint">000597</idno><idno type="wicri:doubleKey">0003-3898:1995:Lacroix C:simultaneous:determination:of</idno><idno type="wicri:Area/Main/Merge">002036</idno><idno type="wicri:Area/Main/Curation">001F80</idno><idno type="wicri:Area/Main/Exploration">001F80</idno><idno type="wicri:Area/France/Extraction">001394</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Simultaneous determination of itraconazole, hydroxy-itraconazole and amphotericin B in human plasma by HPLC with photodiode array detection.</title><author><name sortKey="Lacroix, C" sort="Lacroix, C" uniqKey="Lacroix C" first="C" last="Lacroix">C. Lacroix</name><affiliation wicri:level="1"><nlm:affiliation>Laboratoire de pharmacocinétique, centre hospitalier, Le Havre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de pharmacocinétique, centre hospitalier, Le Havre</wicri:regionArea><placeName><settlement type="city">Le Havre</settlement></placeName></affiliation></author><author><name sortKey="Wojciechowski, F" sort="Wojciechowski, F" uniqKey="Wojciechowski F" first="F" last="Wojciechowski">F. Wojciechowski</name></author><author><name sortKey="Danger, P" sort="Danger, P" uniqKey="Danger P" first="P" last="Danger">P. Danger</name></author></analytic><series><title level="j">Annales de biologie clinique</title><idno type="ISSN">0003-3898</idno><imprint><date when="1995" type="published">1995</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amphotericin B (blood)</term><term>Amphotericin B (therapeutic use)</term><term>Antifungal Agents (blood)</term><term>Antifungal Agents (therapeutic use)</term><term>Chromatography, High Pressure Liquid (methods)</term><term>Humans</term><term>Itraconazole (analogs & derivatives)</term><term>Itraconazole (blood)</term><term>Itraconazole (therapeutic use)</term><term>Mycoses (drug therapy)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Itraconazole</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Amphotericin B</term><term>Antifungal Agents</term><term>Itraconazole</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Amphotericin B</term><term>Antifungal Agents</term><term>Itraconazole</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Mycoses</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Chromatography, High Pressure Liquid</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A method for the fast analysis of itraconazole, hydroxy-itraconazole and amphotericin B is described which has the advantage of speed and specificity. The method is based on methanolic extraction of the compounds from plasma, followed by reverse-phase high-performance liquid chromatography with two detection wavelengths (263 and 405 nm). The extraction step provides > or = 94% recovery and the response of the detection system is linear from 50 to 5000 ng/ml. No other drugs have been found to interfere with the assay.</div></front></TEI><affiliations><list><country><li>France</li></country><settlement><li>Le Havre</li></settlement></list><tree><noCountry><name sortKey="Danger, P" sort="Danger, P" uniqKey="Danger P" first="P" last="Danger">P. Danger</name><name sortKey="Wojciechowski, F" sort="Wojciechowski, F" uniqKey="Wojciechowski F" first="F" last="Wojciechowski">F. Wojciechowski</name></noCountry><country name="France"><noRegion><name sortKey="Lacroix, C" sort="Lacroix, C" uniqKey="Lacroix C" first="C" last="Lacroix">C. Lacroix</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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